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Another special case: If you have angina or coronary artery disease, have had a heart attack, or if you have certain heart-rhythm or heart muscle abnormalities, or heart failure, a beta blocker is the best choice if you are also given a high blood pressure diagnosis.

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Escalating nitrate dose overcomes early attenuation of hemodynamic effect caused by nitrate tolerance in patients with heart failure.

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Thereafter, blood pressure in the two groups was similar.

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Secondary end points were the 12-month and overall mortality during the entire trial period, according to the "intention-to-treat" principle.

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